摘要
目的 探讨准分子激光原位角膜磨镶术 (laserinsitukeratomileusis,LASIK)中眼压急剧升高对视网膜和视神经的影响。方法 将LASIK术中使用的巩膜负压环置于兔眼 ,瞬时压力达到 6 5mmHg( 1mmHg =0 133kPa) ,分别持续 30s、1min及 3min ,在光镜和电镜下观察负压吸引后即刻摘除的 (即刻组 )和 2周后摘除的 (修复组 )兔眼视神经和视网膜组织 ,并与正常兔眼 (对照组 )进行比较。结果 负压吸引 30s,视神经和视网膜细胞改变轻微 ;负压吸引 1min ,部分视神经纤维改变 ,视网膜视细胞出现异常 ;负压吸引 3min ,神经纤维和视网膜视细胞结构明显异常。即刻组和修复组组织改变基本相同。结论 LASIK术中眼压急剧升高 ,可导致视网膜和视神经细胞的亚细胞结构改变 ,且持续时间越长改变越明显。
Objective To study the effect of acute intraocular pressure (IOP) elevation on the optic nerve and retina in laser in situ keratomileusis (LASIK). Methods Acute IOP was increased to 65 mm Hg for different period of time (30 s, 1 min and 3 min) by using scleral suction on rabbit eyes. The tissues of retina and optic nerve of immediately extirpated group (instant group), of 2 weeks later extirpated group (recovery group) both after the negative pressure suction and of normal rabbit eyes were examined with electron and light microscope. Results After the negative pressure suction for 30 s, 1 min, and 3 min respectively, the optic nerve and retinal cells changed lightly; some part of optic nerve and retinal cells changed; optic nerve fibers and retinal cells changed sharply. Conclusion Ultrastructural changes of retina and optic nerve may be induced by acute IOP elevation in LASIK. The longer the time, the more apparent the changes.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2003年第3期136-139,共4页
Chinese Journal of Ophthalmology
