摘要
目的 观察门冬氨酸钾镁与环磷腺苷葡胺注射液治疗重症肺心病并呼吸衰竭的临床疗效 ,肺功能、血气变化及不良反应。方法 将 12 0例重症肺心病患者随机分为治疗组和对照组 ,两组常规治疗相同 ,治疗组加用门冬氨酸钾镁与环磷腺苷葡胺注射液 ,疗程 7～ 10d。比较两组治疗后临床症状 ,体征 ,肺通气功能和动脉血气的改善程度。结果 治疗组和对照组的临床症状和体征改善率分别为 90 %和 70 % ;肺活量 (VC)较治疗前分别增加 (4 15± 112 )mL和 (30 3± 12 4 )mL ;1s用力呼气容积(FEV1.0 )分别增加 (2 2 6± 4 3)mL和 (174± 34)mL ;最大呼气流量 (PEF)分别增加 (0 .81± 0 .2 6 )L/s和 (0 .4 6± 0 .36 )L/s;动脉血氧分压 (PaO2 )分别增加 (2 6 .2± 8.4 )mmHg和 (16 .2± 9.5 )mmHg ;有效率分别为 6 2 .6 %和 4 0 .3% ,两组比较有显著性差异 (P <0 .0 1)。结论 联合使用门冬氨酸钾镁与环磷腺苷葡胺注射液治疗重症肺心病临床疗效和肺功能有显著的改善 ,并且安全 ,不良反应少。
OBJECTIVE To observe the clinical efficacy of potassium-magnesium-aspartate(PMA) and meglumine cyclic adenylate(MCA) injection in treating serious patients with pulmonaty heart desease conconitant respiratory failure. METHOD 120 patients with pulmonary heart desease conconitant respiratory failure were divided into two groups,experimental group and control group.Both of the groups were treated with the same ordinary method. Meanwhile PMA and MCA were given in the experimental group.The period of trearment was 7～10 days. The degree of improvement in clinical symptoms,signs,pulmonary ventilation function and arterial blood gas analysis of the two groups before and after treatment were compared.RESULTS The rates of improvement in clinical symptoms and signs were 90% and 70% in experimental group and control group respectively. VC, FEV 1.0 ,PEF and PaO 2 were incerased 415±112 mL and 303±124mL, 226±43mL and 174±34mL, 0.81±0.26L/s and 0.46±0.36L/s, 26.2±8.4mmHg and 16.2±9.5mmHg compared with the values before treatment in the experimental group and the control group, respectively. There was significant difference between the two groups(P<0.01).CONCLUSION The study shows that combination injection of PMA and MCA are effective and safe in treatment of pulmonary heart desease with respiratory failure.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2004年第2期159-161,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
肺心病
门冬氨酸钾镁
环磷腺苷葡胺
呼吸衰竭
pulmonary heart disease
potassium magnesium aspartate
meglumine cyclic adenylaye
respiratory failure
