摘要
癸甲溴铵是一种新型的消毒药物,目前主要由国外进口。我校有机化学教研室探索了其合成路线,取得了满意结果。合成路线简式为;正癸醇(Ⅰ)→溴代正癸烷(Ⅱ)→二甲基癸胺(Ⅲ)→产品。为确保癸甲溴铵的质量,必须建立一种简单、快速。
The simutaneous separation of two intermediates and their impurities of deciquam was first achieved by capillary gas chromatography within 4 min under following conditions: column, PEG-20M 25 × 0.2 mm I.D. (160℃); detector, FID and nonyl alcohol as the internal standard. The regression equations of Ⅰ , Ⅱ, Ⅲ, were as follows: C=1.95×10^(-2)+0.979A, r=0. 9997; C=1.88×10^(-2)+1.363A, r=0.9997; C=7.07×10^(-3)+0.936A, r=0.9994. The recoveries of three compounds were in the range of 96.13% to 100.0% with coefficient variation less than 1.5%. The factors to affect the accuracy of quantitative analysis were discussed in detail. The method is simple, fast, accurate and suitable for the quality control of deciquam.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1992年第6期376-378,共3页
Journal of China Pharmaceutical University
关键词
气相色谱
癸甲溴铵
Deciquam
Intermediates
Capillary Gas Chromatography
