摘要
探讨了胍基丁胺对谷氨酸诱导PC12细胞DNA损伤的影响。在用一定浓度的谷氨酸诱导PC12细胞DNA断裂的同时,观察胍基丁胺对其DNA断裂和线粒体功能的影响,发现胍基丁胺能明显减轻谷氨酸诱导PC12细胞DNA断裂并能改善线粒体功能。这说明胍基丁胺具有抑制PC12细胞DNA损伤的作用,其机制可能与其拮抗NMDA受体,改善线粒体功能和减轻谷氨酸的氧化毒性有关。
This paper aims to study the effect of agmatine on pc12 cell line injury. The method is to use glutamate with certain concentration to induce DNA injury of PC12 cell line and observe the effect of agmatine on DNA fragment and mitochondrial function simultaneously. It turns out that agmatine can inhibit PC12 cell line DNA injury induced by glutamate through block NMDA-R and improve mitochondrial function and reduce glutamate oxidative toxicity.
出处
《苏州科技学院学报（自然科学版）》
CAS
2004年第1期51-55,共5页
Journal of Suzhou University of Science and Technology （Natural Science Edition）
