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ZD1839治疗恶性纤维组织细胞瘤术后两肺转移1例报告 被引量:2

Successful treatment of pulmonary metastases of malignant fibrous histiocytoma with ZD1839: a case report
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摘要 恶性纤维组织细胞瘤是一种常见的软组织肿瘤 ,恶性程度高 ,易发生转移 ,预后差 ,术后放疗和化疗的作用有限。本文报道了 1例恶性纤维组织细胞瘤术后两肺转移患者 ,肿瘤细胞表皮生长因子受体(EGFR)表达阳性 ,采用EGFR酪氨酸激酶抑制剂ZD1839治疗 1个疗程 (2 8天 )后 ,两肺转移灶全部消失 ,达到完全缓解。 Malignant fibrous histiocytoma (MFH) is a common soft tissue sarcoma, which shows a strong predilection for distant metastases. Due to its limited response to radiotherapy and chemotherapy , poor prognosis is generally observed. A patient with MFH, who developed pulmonary metastases, postoperatively took ZD1839, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, because it was found that there was EGFR expression on the surface of the tumor cells. After a course of treatment (28 days), the pulmonary metastases disappeared, and the patient enjoyed a complete remission.
出处 《解放军医学杂志》 CAS CSCD 北大核心 2004年第2期170-171,共2页 Medical Journal of Chinese People's Liberation Army
关键词 恶性纤维组织细胞瘤 ZD1839 分子靶向治疗 malignant fibrous histiocytoma ZD1839 molecular target therapy
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