摘要
目的 探讨消化道类癌临床病理与多肽 胺类神经内分泌激素抗原表达的关系。方法 应用免疫组化SP法对 36例消化道类癌组织中 6种抗原表达进行检测。结果 36例类癌组织中 5 羟色胺、胰高血糖素和生长抑素较多表达于组织分化好的类型 ,其与肿瘤的侵袭和转移无相关性。胃泌素的表达随肿瘤组织分化降低而上升显著(P <0 .0 5 ) ,胃泌素高表达促进肿瘤的浸润和转移 ,生长抑素随着肿瘤的浸润和转移阳性表达率降低 (P <0 .0 5 ) ,有抑制肿瘤浸润和转移的作用 (P <0 .0 5 )。结论 胃泌素、生长抑素可能与细胞膜上相应受体结合 ,促进或抑制肿瘤细胞增殖。提示应用多种抗原标记对预测类癌的生物学行为和预后很有帮助。
Objective To study the relationship between clinical pathology and antigen expression of polypeptide/ amine neuroendocrine hormone.Methods The immunohistochemistry SP method was adopted to examine the expression of six different antigens in thirty six cases of gastrointestinal carcinoid.Results 5 HT,glucagon and somastatin were mostly expressed in typical carcinoid, 5 HT and glucagons had no correlation with the invasion and metastasis of carcinoid. For gastrin, the positive rates increased with the poor differentitation ( P <0.05).High expression of gastrin can stimulate the invasion and metastasis of carcinoid, for somastatin, the positive rates decreased with the poor differentitation and it could inhibit the invasion and metastasis( P < 0.05 ).Conclusion When gastrin and somastatin combine with the membrane receptor of cell, they can stimulate or inhibit the proliferation of the tumor cells. These data indicate that many kinds of antigens may be valuable markers to predict the biologic behavior and prognosis in gastrointestinal carcinoid.
出处
《哈尔滨医科大学学报》
CAS
2004年第2期157-159,共3页
Journal of Harbin Medical University
基金
哈尔滨市青年科学研究基金项目 ( 2 0 0 3AFQ X J O 43 )
关键词
消化道类癌
临床病理
免疫组化
肿瘤
carcinoid
neuroendocrine carcinoma
immunohistochemistry
polypeptide/amine neuroendocrine hormone
