摘要
目的 :探讨二甲双胍联合胰岛素对 2型糖尿病经磺脲类治疗失效病人的疗效及安全性。方法 :72例磺脲类失效的 2型糖尿病病人分为 2组 ,A组 38例 [男性 18例 ,女性 2 0例 ,年龄 (5 6±s12 )a],每日 2次预混人胰岛素 (优泌林 70 / 30 )皮下注射。B组 34例 [男性 16例 ,女性 18例 ,年龄 (5 7± 10 )a],除每日 2次预混人胰岛素皮下注射外 ,加用二甲双胍 2 5 0mg,po ,tid。根据血糖调整胰岛素剂量。结果 :A组的有效胰岛素剂量 (36± 11)IU·d- 1显著高于B组 [(30± 11)IU·d- 1](P <0 .0 5 )。治疗过程中有 4例出现低血糖反应。不良反应发生率为5 %。结论 :2型糖尿病磺脲类失效者口服二甲双胍联合胰岛素治疗可较有效地控制血糖 ,且胰岛素用量和不良反应少。
AIM: To explore the effective dosdage of insdulin in type 2 diabetes mellitus patients to failed sulfonylureas treatment. METHODS: Seventy two patients of type 2 diabete mellitus were seporated into two groups, group A (M 18, F 20; age (56± s 12) a) were treated with mixed split human insulin (Humlin 70/30) only and group B (M 16, F18; age (57±10) a) were treated with Humlin 70/30 combined with metformin 250 mg , po , tid. Adjust the quantity of Humlin according to blood glucose. RESULTS: The efffective insulin dosage ((36±11) IU·d -1 ) of group A is significantly higher than that of group B ((30±11) IU·d -1 ). The adverse reaction rate were 5 % . CONCLUSION: Using insulin combined with metformin is better than insulin alone in type 2 diabetes mellitus with sulfonylurea failure.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2004年第4期221-223,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
糖尿病
磺酰脲化合物
胰岛素
二甲双胍
diabetes mellitus
sulfonylurea compounds
insulin
metformin
