摘要
Gwe 是一种来自中药的免疫调节剂.实验证明,它能明显抑制由环磷酰胺引起的骨髓细胞微核的形成,减少脾细胞染色体畸变的发生,降低脾细胞姊妹染色单体互换频率,同时能够降低由环磷酰胺引起的 IL—6生成的增高.
Gwe is a new immunological response modifier extracted from a traditional Chinese drug.In our experiments,we demonstrated that:1.Gwe could significantely inhibite micronucleus fre-quencies in bone marrow cells of mice and decrease both the chromosomal aberrations(CA)andsister—chromatid exchange freqencies of splenocytes in mice induced by Cy;2.it could decreasethe activities of IL—6 like substance of splenocytes in mice induced by CY;3.there was a posi-tive correlation between IL—6 activities in the supernatant from cultured spleen cells and mi-cronucleus frequences in bone marrow cells or CA frequences in spleen cells.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1992年第6期376-378,共3页
Chinese Journal of Immunology
关键词
骨髓细胞
微核
染色体畸变
Gwe
Gwe
Micronucleus
Chromosome aberrrations
Sister-chromatid exchange
IL-6
