摘要
目的:探讨白细胞介素-1β(IL-1β)在溃疡性结肠炎(UC)中的作用。方法:采用ELISA法测定105例UC患者及60例正常对照血清IL-1β的含量。结果:活动性UC患者IL-1β含量((62.32±13.23)ng/L)显著高于缓解期UC患者((55.47±12.48)ng/L)和正常对照组((53.82±15.79)ng/L)(P<0.05);不同病变范围IL-1β的含量:全结肠炎组((66.77±13.39)ng/L显著高于左半结肠炎组((58.71±11.00)ng/L)和远端结肠炎+直肠炎组((57.20±11.75)ng/L)(P<0.05)。结论:UC患)者血清中IL-1β含量与病变活动、范围有关,IL-1β的变化可作为监测UC活动及疗效判定的指标之一。
Aim : To evaluate the effect of interleukin-1β( IL-1β) on the ulcerative colitis (UC). Methods: The serum levels of IL-1β in 74 active and 31 inactive UC patients and 60 normal controls were measured by ELISA. Results: The level of serum IL-1β in active stage of patients with UC ( (62. 32±13. 23) ng/L) was higher than those of inactive stage patients ( (55.47±12. 48) ng/L) and normal control ( (53.82±15. 79) ng/L) ( P < 0. 05 ). The level of serum IL-1β in the pan-colitis( (68.77±13. 39) ng/L) was higher than those of left-sided colitis ( (58. 71±11. 00) ng/L) and proctosigmoiditis( (57.20±11.75) ng/L) (P <0.05). Conclusion: The level of serum IL-1β in patients with active UC was higher than those of inactive UC and normal control; the level of serum IL-1β in the pan-colitis were higher than that of left-sided colitis and proctosigmoiditis. The results suggest that the level of IL-1β in serum can be an indicator of the activity of UC.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2004年第2期306-308,共3页
Journal of Zhengzhou University(Medical Sciences)
