摘要
目的:探讨肾母细胞瘤组织中Cath D、uPA、uPAR的表达。方法:用免疫组化SABC法检测30例肾母细胞瘤及15例非肿瘤肾组织中Cath D、uPA、uPAR的表达。结果:肾母细胞瘤组织中Cath D、uPA、uPAR的阳性表达率分别为50％,53.3％和56.7％。而在非肿瘤肾组织中不表达,差异有统计学意义(P<0.05),3者的阳性表达率与组织学类型密切相关,FH型均低于UH型(P<0.05)..结论:Cath D、uPA、uPAR在肿瘤的浸润和转移中起重要作用,可作为预后的指标。
Aim : To detect the expressions of Cath D, urokinase-type plasminogen activator ( uPA) and its receptor (uPAR) in nephroblastoma and reveal the correlation with histological type. Methods: The expressions of Cath D, uPA and uPAR as well as its correlationship with tumor histological type in 30 specimens of nephroblastoma and 15 non-tumor kidney tissues were retrospectively studied by using SABC immunohistochemistry. Results: The positive rates of expression of Cath D , upA , uPAR in nephroblastoma group were 50% , 53. 3% , 56. 7% respectively, but there were no positive staining in non-tumor kidney tissues. There were significant difference(P <0.05). The expressions of Cath D, uPA, uPAR were closely related to histological type. The expressions in FH were weaker than in UH ( P <0. 05). Conclusion; The findings suggest that Cath D, uPA and uPAR play an important role in invasion and metastasis of nephroblastoma. Cath D, uPA and uPAR might be independent predictors of prognosis.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2004年第2期217-219,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省科技攻关基金资助项目 324410085
