摘要
目的 探讨脑血栓急性期患者血浆内皮素 (ET)水平 2 4h内动态变化规律及其与发病的相关性。方法 采用放射免疫分析对 32例脑血栓患者和 2 0名健康人在 2∶0 0、8∶0 0、14∶0 0、2 0∶0 0时 ,分别测定其血浆ET水平的动态变化。结果 脑血栓患者昼夜血浆ET水平明显增高 ,与对照组比较差异均有极显著性 (t=2 9.1～30 .5 ,P均 <0 .0 0 1) ,且在 2 4h内 2∶0 0时ET水平最低 ,8∶0 0时最高 ,两者比较差异有显著性 (t =5 .6 7,P <0 .0 1)。有高血压和糖尿病病史的脑血栓患者 2 4h内ET水平均较无高血压、糖尿病病史者显著增高 (t =2 .37～ 8.39,P <0 .0 5、0 .0 1)。结论 脑血栓急性期患者血浆ET水平 2 4h内有早晨高和晚上低的节律性变化 ,其变化与脑血栓发病以早晨为高发时间的现象一致。
Objective To study plasma endothelin (ET) level fluctuation in patients with cerebral thrombus in acute stage within 24 hours and to analyse the relationship between plasma ET level and morbidity. Methods Plasma ET level was measured in 32 patients with cerebral thrombus and 20 normal human at 2∶00, 8∶00, 14∶00 and 20∶00 respectively by radioimmunoassay (RIA). Results Day or night plasma ET level in patients with cerebral thrombus obviously increased and they both had a significant differecne in comparison with controls ( t = 29.1 -30.5, P < 0.001 ). Plasma ET level was the lowest at 2∶00 and the highest at 8∶00 during 24 hours. There was a significant difference between them ( t =5.67, P <0.01). ET level in patients with cerebral thrombus who either had hypertension or diabetes mellitus history was significant higher than those without hypertension or diabetes mellitus history. Conclusions Plasma ET level in patients with cerebral thrombus in acute stage presents a fluctuation with circadian rhythm high in the morning and low at night. These changes are in accordance with the phenomenon that the morbidity peak of cerebral thrombus is in the morning.
出处
《检验医学》
CAS
北大核心
2004年第2期98-100,共3页
Laboratory Medicine
