摘要
以2,4-二氯-5-氟苯甲酰乙酸乙酯为原料,经过乙氧甲叉化、氨化、环合、水解、缩合、还原等步骤,合成了17个N1-位为取代吡咯基和对硝基苯基的吡酮酸类化合物,测定了对大肠杆菌和金葡球菌的体外活性,讨论了这些化合物的构效关系。
Seventeen quinolone compounds, characterized by having fluorine atom at 6-position, substituted amino at 7-position, and substituted pyrrolyl or p-nitro phenyl at 1-position, were synthesized.The antibacterial activities in vitro of these compounds against E. coli and S.au-reus were tested. The Structure-activity relationship of these compounds has been discussed.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1992年第3期219-222,共4页
Chinese Journal of Antibiotics
基金
中国医学科学院科研基金资助课题
关键词
吡酮酸
合成
抗菌活性
构效关系
Pyridonecarboxylic Acid
Synthesis
Antibacterial activity in vitro
Structure-Activity Relationship
