摘要
43例健康人和175例心脏病患者作心—肺运动试验,以评价心功能不全的程度。采用自行车运动递增负荷试验,通过监测每分钟换气量(V_E)、氧摄取量(V_(O2))和二氧化碳排出量(V_(CO2))来确定无氧代谢阈值(AT)。同时也测定峰值V_(O2)(PV_(O2))和%AT。AT(ml/min/kg)和PV_(O2)(ml/min/kg)随年龄增大而下降,男性的上述值均高于女性。%AT值(从年龄和性别预测的AT值经校正后的AT百分数)在心功能不全组随NYHA级别增高而降低;心功能Ⅰ、Ⅱ、Ⅲ级分别为85.3±10.3%,74.7±14.1%和58.8±12.8%。间隔3小时所测AT值重复性好。结果表明,心—肺运动试验的指标,特别是AT与心功能不全的病理生理有密切关系,因此,AT可以作为评价心功能不全的客观指标,并可用于评价心功能不全治疗的效果。
Cardio-pulmonary exercise was performed in 43 normal subjects and 175 patients with cardiac disease in order to evaluate the severity of heart failure. AT could be determined easily during bicycle ergometer exercise by measuring minute ventination (V_E), oxygen uptake (V_(O2)) and carbon dioxide output (V_(CO2)). Peak V_(O2) and % AT were also determined, Both AT(ml/min/kg) and peak V_(O2) (ml/min/kg) declined with age, how ever male showed higher values than femal in both indiceS, % AT (determined by the predicted AT values of each age and sex), decreased as class of NYHA progressed (i. e. 85.3±10.3% in class Ⅰ, 74.7±14.1% in class Ⅱ, and 58.8±12.8% in class Ⅲ). The reproducibility of AT was excellent in two testing With in a 3-hour interval. These results suggested that indices from cardio-pulmonary exercise testing, especially AT, were closely related to the pathophysiology of heart failure so that they might be used as an objective parameters and were reliable for evaluation of the severity of heart failure and are sensitive enough to detect the efficacy of therapuetic intervention for heart failure.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1992年第6期625-629,共5页
Chinese Journal of Pathophysiology
