摘要
本文报告了通痹片的急性毒性实验、对大鼠及犬的长期毒性实验结果,对小鼠:LD_(50)为5.29g/kg。犬口服0.513g/(kg×d)(为小鼠LD_(50)的1/10),连续给药6个月、4个月后出现类似士的宁中毒症状,且BUN升高,停药后恢复正常。犬口服0.051g/(kg×d)连续6个月,大鼠各剂量组均未出现中毒症状,提示该药的临床用量是安全的。
This paper reported the acute toxicity test and the long-term toxicity test of Tongbi Tablets in rats and dogs. The LD_(50) of mice was 5.29g/kg. For dogs following oral administration (0.513g/kg/day, which was a tenth part of mice'LD_(50)) for 6 months running, the toxic symptom of strychnine-like and an increase in BUN could be-observed after 4-month administration. Both recoveried after breaking off the administration. For 0.051g/kg/day dosage group of dogs(administered for 6 months running)and all dosage groups of rats, no toxic symptom was observed, suggesting that the clinical dosage of this medicine was safe.
出处
《中成药》
CAS
CSCD
北大核心
1992年第12期26-27,共2页
Chinese Traditional Patent Medicine
关键词
通痹片
毒性
Tongbi Tablets,acute toxicity test,long-term toxicity test
