摘要
目的 探讨人工流产术前扩张宫颈的有效方法及途径。方法 将 90例早孕要求负压吸宫术终止妊娠的初孕妇女按随机表法分为 3组 :米索前列醇口服组及阴道后穹窿上药组各 30例 ,宫颈插管组 30例。药物组分别于施术前 3h口服及阴道后穹窿置米索前列醇 6 0 0 μg ,宫颈插管组插入 1 6号橡胶导尿管 5cm于宫颈管内进行术前准备 ,观察各组有效宫颈扩张度 (≥7.0mm)比率 ,术中出血量 ,手术时间及副反应发生率。结果 3组有效宫颈扩张度比率 ,以阴道后穹窿置药组显著高于口服及插管组 (P <0 .0 5 ) ,服药组与插管组相比无显著性差异 ;3组术中出血量比较 ,米索前列醇口服组与阴道上药组间差异无显著性 (P >0 .0 5 ) ,但宫颈插管组与此两组的术中出血量相比差异非常显著 (P <0 .0 1 ) ;手术时间以米索前列醇阴道上药组最短 ,宫颈插管组最长 ,但 3组间无统计学差异 ;用药后副反应发生率 ,宫颈插管组显著低于米索口服组及阴道上药组 (P <0 .0 5 ) ,米索口服组及阴道上药组间相比差异无显著性 (P >0 .0 5 ) ,但口服组胃肠道反应发生率显著高于阴道上药组 ,而阴道上药组的术前出血率又显著高于其余两组 (P <0 .0 5 )。结论 米索前列醇阴道内置入是人工流产术前扩张宫颈的理想给药途径 。
Objective To explore an effective method and route for cervical dilatating before mannul surgical abortion.Methods Ninety early pregnant women who sought termination of pregnancy by vacuum aspiration were randomly divided into three groups (30 cases each):oral misoprostol group,in which 600μg misoprostol was orally administered three hours before surgery;vaginal misoprostol group,in which 600μg misoprostol was vaginally administered three hours before surgery;intracervical catheter group,in which Forley catheter of size sixteen was intracervically placed by 5 cm depth before surgery.The amount of cervical dilatation , volume of intraoperation blood loss, time duration of the surgery,and rate of complications of three groups were observed.Results The amount of cervical dilatation of the vaginal misoprostol group is significantly greater than that of the oral misoprostol group and the intracervical catheter group( P <0.05) ,while there is no difference between the latter two groups.There is no difference between the volume of blood loss of the oral misoprostol group and that of the vaginal misoprostol group( P >0.05) ,while there is significant difference between the former two groups and the intracervical catheter group( P <0.01). Time duration of the vaginal misoprostol group is the shortest,and the intracervical catheter group is the longest,while there is no statistical difference among three groups.The rate of complications of intracervical catheter group is significantly lower than that of oral misoprostol group and vaginal misoprostol group( P <0.05),and there is no difference between the oral misoprostol group and vaginal misoprostol group( P >0.05).While rate of gastrointestinal complications in oral misoprostol group is significantly greater than that of vaginal misoprostol group,and rate of blooding in vaginal misoprostol group is significantly greater than that of the other two groups.( P < 0.05 ).Conclusions Vaginal route of misoprostol is an optimal route for
出处
《重庆医学》
CAS
CSCD
2004年第3期422-423,共2页
Chongqing medicine
关键词
米索前列醇
人工流产
扩张宫颈
misoprostol
induced abortion
cervical dilatating
