摘要
目的 观察小剂量麻黄碱减轻老年人异丙酚麻醉诱导心血管抑制反应的临床疗效。 方法 4 0例年龄大于 6 5岁拟行全麻择期手术患者 ,随机分为A组 (对照组 )和B组 (麻黄碱组 ) ,每组 2 0例。两组均用异丙酚、芬太尼和阿曲库胺静脉注射诱导。异丙酚用量为 1.8mg/kg ,B组麻黄碱用量为 0 .18mg/kg。记录两组患者在诱导前 (T0 )、诱导后 1min(T1)、3min(T2 )、插管即刻 (T3 )、插管后 2min(T4)、5min(T5)的SBP、MAP、HR变化。 结果 A组T1、T2 、T4、T5的SBP、MAP均明显下降 (P <0 .0 1或 P <0 .0 5 ) ,B组T2 的SBP、MAP有非常明显下降 (P<0 .0 1)、T5的SBP、MAP明显下降 (P <0 .0 5 ) ;B组下降的程度较小 ,组间对比有显著性差异 (P <0 .0 1或P <0 .0 5 )。HR在T3 均明显增快 (A组 :P <0 .0 1,B组 :P <0 .0 5 ) ,组间对比无显著性差异。 结论 小剂量麻黄碱能明显地减轻老年人异丙酚麻醉诱导的心血管抑制反应。
Objective To observe the curative effects of the small dose of ephedrine to relieve cardiovascular inhibitory response of the elderly patients who were under anesthesia induction with propofol.Methods 40 elderly patients scheduled for undergoing surgery who were under general anesthesia were randomly assigned into two groups, Group A (contrast group) and group B (ephedrine group),with 20 cases each. The patients of the two groups were both induced with propofol,fentanyl and atracurium. The dosage of propofol is 1.8mg/kg.The ephedrine’s dosage of group B is 0.18 mg/kg.Recording the SBP,MAP,HR’s changes of the two groups before induction (T 0),1 minute(T 1) and 3 minute(T 2) after induction,immediately after tracheal intubation(T 3) ,2 minute(T 4) and 5 minute(T 5) after intubation. Results T 1, T 2,T 4, T 5’s SBP,MAP of the patients decreased significantly in group A (P<0.01 or P<0.05). T 2,T 5’s SBP,MAP of the patients decreased significantly in group B (P<0.01 or P<0.05). The degree of decreasing was smaller in group B than that in group A. There were significant differences between the two groups (P<0.01 or P< 0.05 ). HR quickened obviously in T 3. There was no significant difference between the two groups. Conclusion The small dose of ephedrine can relieve cardiovascular inhibitory response of the elderly patients significantly under anesthesia induction with propofol.
出处
《医药论坛杂志》
2004年第3期11-13,共3页
Journal of Medical Forum
