摘要
目的 分析氨基糖甙类抗生素源性急性肾功衰 (ARF)的临床特征、诊治与预后 ,为药源性ARF防治提供理论依据。方法 回顾性分析我院 5 7例氨基糖甙类抗生素源性ARF患者的临床资料。结果 ① 5 7例氨基糖甙类抗生素源性ARF ,占我院同期收治ARF的 18 0 %、药源性ARF的 5 8 0 % ;② 4 1例患者年龄大于 6 0岁 ,占 71 9% ,且多合并有系统性疾患或其他诱发加重因素 ,肾功能损害多见于运用氨基糖甙类抗生素后 4～ 13天 ;③ 4 8例 ( 84 2 % )患者无明显少尿或多尿 ,37例患者 ( 6 5 % )未能获得及时的诊治 ;④本组患者 4 8例临床治愈 ,7例发展至慢性肾功能不全 ,2例死亡 ,总有效率为 84 2 %。结论 氨基糖甙类抗生素源性ARF是住院病人药源性ARF的常见病因 ,多见于老年患者 ,其临床表现不典型 ,误诊漏诊率高 。
Objective To investigate the clinical spectrum of aminoglycosides induced acute renal failure(ARF) and trovide the reasonable basis for the trevention and care of drug induced ARF Methods The clinical data of 57 aminoglycosides induced ARF were analyzed retrospectively Results?①The incidence of aminoglycosides induced ARF was 18 0% among all ARF and 57 9% among the drug induced ARF during a period of 1998～2002 in our hospital;②41(71 9%)patients of our group were older than 60 years,and most of the patients complicated with other systemic diseases and risk factors of ARF;the damage of renalfundion often happened 4～13 days after the use of aminoglycosides.③48(84 2%)patients of our group had no significant oliguria or anuria,and 37(65%)patients did not get seasonable dagnosis;④After treatment,48 patients got remission,7 patients developed to end stage renal failure,and 2 dead Conclusion Aminoglycosides induced ARF is one of the main cause of drug induced ARF,with untypical manifestations and higher incidence of misdiagnosis and more heppens in old patients,and need more attention to it's diagnosis and treatment
出处
《实用医院临床杂志》
2004年第2期55-56,共2页
Practical Journal of Clinical Medicine
