摘要
目的 总结膀胱癌肉瘤的组织发生、临床及病理特点。 方法 报告 2例膀胱癌肉瘤 ,男女各 1例 ,均以间断性无痛肉眼血尿收入院 ,对其组织病理及临床经过进行分析。 结果 2例膀胱镜均示息肉或菜花样肿物 ,呈浸润性生长 ,表面可见钙化 ,CT示膀胱壁实质性占位。 2例均行膀胱部分切除术 ,术中所见与膀胱癌基本相同。病理可见上皮和间质两种恶性成分 ,上皮部分由高分级移行细胞组成 ,上皮之间混杂有恶性间质成分 ,呈异常增殖状 ,可见有丝分裂相。术后应用溶肉瘤素治疗 ,1例术后 11个月死亡 ,另 1例术后 16个月死亡。 结论 膀胱癌肉瘤具有高度恶性和浸润性生长的生物学特性 ,预后不良。对间断无痛性肉眼血尿患者应警惕本病发生。
Objective To investigate the histogenesis and clinicopathologic features of carcinosarcoma of the urinary bladder. Methods Two cases of carcinosarcoma (one man and one woman)were included.They were admitted to hospital with discontinuous,painless,macroscopic hematuria.Clinicopathalogic features of all findings of the 2 cases were reviewed. Results Cystoscopy of both cases showed that the tumors displayed polypous or cauliflower-like shape,and grew invassively.CT examination of the bladder wall confirmed the presence of parenchymatous tumor.Both of the 2 cases underwent partial cystectomy.Intraoperative examination showed the tumors were similar to carcinoma of bladder.Histopathology showed biphasic neoplasms with distinct high grade epithelial and mesenchymal components.Morphologic characteristic of the tumor was abnormally proliferative and the mitotic figures could be seen.One of the patients died within 11 months and the other,16 months following the operation. Conclusions Carcinosarcoma of the urinary bladder is a kind of rare malignant tumor that is most often in an advanced stage at presentation and has an unfavorable prognosis. It should be identified promptly and treated appropriately.Those who have discontinuous,painless,macroscopic hematuria should be warned of the risk of the disease.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2004年第3期183-184,共2页
Chinese Journal of Urology
