摘要
目的 探讨肝细胞癌 (HCC)中P2 7蛋白表达与细胞凋亡的关系。方法 应用免疫组化S P法和DNA末端标记技术TUNEL法检测 86例HCC中P2 7蛋白的表达和细胞凋亡情况。结果 P2 7蛋白在肝癌组织中阳性率为 37.2 % (32 / 86 )。P2 7蛋白阳性组的细胞凋亡指数 (AI)均数为 6 .72‰ ,阴性组为 2 .83‰ ,两者比较有显著性差异 (P <0 .0 1)。结论 HCC中P2 7蛋白表达与细胞凋亡有密切关系 ,促进细胞凋亡可能是其抑癌机制之一。
Objective To study The relationship between apoptosis and expression of P27 protein in hepatocellular carcinoma(HCC).Methods P27 protein and apoptotic cells were detected by immunohistochemical S-P method and TUNEL method in 86 paraffin-embedded tissues of HCC.Results The positive rate of P27 protein in these tissues was 37.2%(32/86). The mean apoptotic index in the HCC with positive expression of P27 protein (6.72‰) was significantly higher than that in the negative group (2.83‰). Conclusion Expression of P27 protein related significantly with cell apotosis of HCC. Promoting apoptosis may be one of the effective anti-cancer mechanisms of P27 protein.
出处
《右江医学》
2004年第1期1-2,共2页
Chinese Youjiang Medical Journal
