摘要
目的 评价红霉素作为胸膜硬化剂治疗自发性气胸的价值。方法 复发性自发性气胸患者 4 7例 ,红霉素 1g溶于 5 0ml生理盐水中注入患侧胸膜腔内治疗胸膜腔粘连。结果 红霉素治疗总有效率为 85 1% ,一次注药有效率为 5 7 4 % ,仅 4例多发性肺大疱患者复发。胸液分析显示为炎性改变。不良反应主要为胸痛 ,发生率为 4 2 5 % ,其中 16 1%的患者疼痛较剧烈 ,给予止痛剂可缓解。复发率为 10 3%。结论 红霉素可作为一种有效的胸膜硬化剂治疗自发性气胸。
Objective To investigate the value of erythromycin as a pleural sclerosant in the treatment of spontaneous pneumothorax.Methods A dose of 1 g erythromycin in 50 ml 0.9% saline was injected into the pleural cavity of forty seven patients with spontaneous pneumothorax.Results After injection of erythromycin the total response rate was 85.1% and the efficacy rate after the first treatment was 57.4%.The recurrent rate was 10.3% with chest pain as major side-effect.The thoracentesis analysis showed that erythromycin-induced pleurodesis is the result of pleural chemical inflammation.Conclusion This study indicates that erythromycin may have a potential role as a useful pleural sclerosant in treating spontaneous pneumothorax.
出处
《中国呼吸与危重监护杂志》
CAS
2004年第2期110-112,共3页
Chinese Journal of Respiratory and Critical Care Medicine
