摘要
目的:了解天疱疮、类天疱疮及皮肌炎3种自身免疫性疾病合并恶性肿瘤的情况。方法:分析92例天疱疮患者、60例类天疱疮患者、174例皮肌炎患者的临床特点以及与肿瘤发生的相关因素。结果:肿瘤发生率在类天疱疮患者为10.00%,天疱疮患者为6.52%,皮肌炎患者为12.07%。与肿瘤发生可能相关的因素包括:天疱疮患者的病程(P=0.032,OR=0.718),皮肌炎患者的发病年龄(P=0.012,OR=1.053)以及应用甲氨喋呤(MTX)(P=0.032,OR=0.273)。结论:天疱疮、类天疱疮与恶性肿瘤的发生无肯定的相关性,而皮肌炎与恶性肿瘤相关。
Objective:To investigate the relationship between pemphigus,pemphigoid,dermatomyositis and accompanied malignancies.Methods:We retrospectively analyzed92cases of pemphigus,60cases of pemphigoid and174cases of der-matomyositis who were admitted to Peking Union Medical College Hospital from1990to2001.Results:It was found that the incidences of associated malignant tumors were10.00%(6/60)in pemphigoid,6.52%(6/92)in pemphigus and12.07%(21/174)in dermatomyositis respectively.Statistical analyses revealed that high risk factors for malignancies included the duration of pemphigus(P=0.032,OR=0.718),the age of the onset(P=0.012,OR=1.053)and the application of MTX(P=0.032,OR=0.273)in dermatomyositis respectively.Conclu sions:The results suggest that there are no certain relationships between the malignant tumors and pemphigus or pemphigoid,while dermatomyositis is associated with high rate of malignancy.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2003年第6期327-328,共2页
Journal of Clinical Dermatology
关键词
天疱疮
类天疱疮
皮肌炎
肿瘤
pemphigus
pemphigoid
dermatomyositis
tumor
