摘要
目的 :评价浸润性导管癌间质肌成纤维细胞的临床病理学意义。方法 :用免疫组化的方法研究5 8例乳腺浸润性导管癌间质成纤维细胞α SMA的表达情况 ,分析其与年龄、肿瘤大小、淋巴结转移、组织学分级、雌激素受体状态的关系。结果 :33例 (5 6 .9%)浸润性导管癌间质成纤维细胞有α SMA表达 ,而正常乳腺组织和导管原位癌间质成纤维细胞中则无α SMA表达 ;间质成纤维细胞α SMA表达与患者年龄、肿瘤大小和雌激素受体状态无关 ,与淋巴结转移状态和组织学分级有关。结论 :肌成纤维细胞特异性地出现在浸润性导管癌间质中 ,在一定程度上反映了肿瘤的恶性程度。
Objective:To observe smooth muscle differentiation of stromal fibroblasts in breast cancer and assess its clinicopathological significance.Methods:A monoclonal antibody recognizing α-smooth muscle actin was used to study smooth muscle differentiation of stromal fibroblasts in 58 cases with infiliative ductal carcinoma of the breast.The relationship between myofibroblasts positivity and clinicopathological traits was analyzed.Results:Stromal myofibroblasts were observed in 56.9% of the partients with infiliative ductal caricinoma ,whereas no immunostain was demonstrated in in situ cancer and histolotgically normal samples.69.4% (25/36) of the cases with metastatic lymph node showed myofibroblasts,the expresion rate was higher than the negative lymph node group (39.1%).Grade Ⅱ,Ⅲ group had a higher myofibroblast positivity than grade Ⅰ.Conclusion:Myofibroblasts appearing with in the infiliative ductal carcinoma of the breast may contribute to the invasion and metastasis of breast cancer.
出处
《中国现代普通外科进展》
CAS
2003年第3期153-155,共3页
Chinese Journal of Current Advances in General Surgery
