摘要
目的 :评价食管镍钛合金支架置入术联合放射治疗晚期食管癌的临床可行性和疗效。方法 :对 88例晚期食管癌并穿孔、瘘、狭窄病人分别行镍钛合金带膜支架置入术和支架联合放射治疗 ,比较单纯支架治疗和联合放射治疗病人的生存率和疗效 ;观察JMZ型镍钛合金支架对放射治疗射线分布的影响。结果 :① 6、9、12个月的生存率联合放射治疗组病人分别为 77.3 %、52 .3 %、3 1.8% ,单纯支架组分别为 79.5%、50 .0 %、13 .6% ,两组比较无统计学意义 (P >0 .0 5) ,但合并症联合放疗组高于单纯支架组 ;②食管癌伴狭窄病人 12、2 4个月生存率联合放疗组分别为 73 .6%、3 6.8% ,单纯支架组分别为 3 0 %、0 ,两组比较有显著差异性 (χ2 =18.9841,P =0 .0 0 0 1) ;③JMZ型镍钛合金支架对食管癌放射治疗剂量分布影响在± 2 %左右。结论 :晚期食管癌合并穿孔、瘘病人支架置入术联合放射治疗不能提高生存率 ,而且增加合并症 ;支架置入术联合放射治疗可应用于合并食管狭窄的病人 ,提高一、二年生存率 ,值得临床进一步研究 ;
Purpose:To study clinical feasibility and results of endoscopic metal stenting combined with radiotherapy in treatment of late stages of esophageal carcinoma.Me thods:88 cases of late stages of esophageal carcinoma were randomized i nto two groups :one (group A) treated with stent implantation only, another (gr oup B) combination of stent and radiotherapy. To observe the effect of JMZ metal stent on the distribution of X rays and to compare clinical efficacy and surviv al rates of two groups.Results:① The 6-?9-?12- months survival rates were 79.5%, 50.0%.and 13.6% ; 77.3%, 52.3% and 31.8% respectively (P>0.05),.But the com plication rates of group B were higher than group A;②The survival rates of 12 -?24- months of patients with stricture were significantly higher than those no without in group B;③JMZ stainless stent had no effect on radiation dosage d istribution .Conclusions:Endoscopic metal stenting in combination with radio therapy did not improve the survival rates in treatment of late stages of esopha geal carcinoma with fistula,but the complication rates were higher. However, the 1-?2-years survival rates of esophageal carcinoma with stricture were improv ed . JMZ stainless stent had no effect on radiation dosage distribution.
出处
《中国癌症杂志》
CAS
CSCD
2004年第1期65-67,共3页
China Oncology
