摘要
多胺与细胞生长及凋亡有密切的关系。多胺与细胞凋亡关系的研究将为细胞生长及抑癌研究提供科学的基础资料。文章主要从多胺的合成及分解 ,腐胺、精胺、ODC和 SSAT在细胞凋亡过程中的作用及 Caspase-3、P53、MAPK /JNK和原癌基因等参于多胺介导的细胞凋亡的调节机理等方面 。
There is an intimate relationship between polyamine and the growth of cells,these polyamines mainly include putrescine,spermidine and spermine . The studies on polyamine and cells apoptosis will provide scientific materials for the study of cells growth and anticarcinoma.This article elucidated as far the links between polyamine and cells apoptosis by giving some information about metabolism of polyamine,the relationship of polyamine and cells growth or apoptosis and the mechanism of polyamine modulation,these informations mainly include the effect of putrescine,spermine, ODC and SSAT on cell apoptosis,and metablism of polyamine modulating cell apoptosis by Caspase-3,P^(53),MAPK/JNK and oncogene way.
出处
《动物医学进展》
CSCD
2004年第2期11-14,共4页
Progress In Veterinary Medicine
基金
国家自然科学基金资助 (3 950 0 10 8
3 0 2 70 960
