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妊高征外周血小板活化和红细胞钙含量的临床分析

The study on platelet activated molecules and intracellular free calcium of erythrocyte in pregnancy induced hypertension
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摘要 目的 探讨不同程度妊高征患者外周血小板活化和红细胞内Ca2+含量(IECa2+)的改变及其临床意义。方法 以三种血小板膜糖蛋白单克隆抗体CD62p、CD61、CD41标记50例正常孕妇和56例妊高征患者外周血小板,并应用Fluo-3/AM导入红细胞,用流式细胞仪检测之水平与Ca2+含量。结果 正常孕妇血小板CD62p、CD61及CD4l的检测值分别为7.16%±3.10%、5.60%±2.78%及8.31%±4.31%;妊高征随程度的加重三种分子呈增高趋势,且重度组检测值显著高于正常组和轻、中度组(P<0.05、P<0.01)。轻度组产前及产时IECa2+与正常妊娠无显著性差异(P>0.05),重度妊高征者增加(P<0.05),IECa2+含量与平均动脉压(MAP)呈正相关,发生胎儿宫内窘迫妊高征患者IECa2+含量较未发生者明显增加(P<0.05)。结论 妊高征外周血小板CD62p、CD61及CD41检测值显著增加,标志着血小板活化程度和凝血能力明显增强,IECa2+增加能够预示胎儿宫内窘迫的发生;采取有效的降压措施可以使IECa2+含量趋于正常水平以减低其危害。 Objective To investigate the platelet activated molecules and intracellular free calcium of erythrocyte (IECa2+) in pregnancy induced hypertension (PIH) and their clinical significance. Methods Fifty normal pregnancy women and fifty-six with PIH were studied,their platelet activated molecules (CD62p, CD61,CD41) and IECa2+ levels using Flu-3/AM by flow cytometry. Results The CD62p,CD61, CD41 levels of platelet normal pregnancy women were 7.16%±3.10%, 5.60%±2.78% and 8.31%±4.31%. The higher the content of hypertension was, the higher CD62p,CD61,CD41 levels were. The platelet activated molecules (CD62p,CD61,CD41) and IECa2+ levels in the severe PIH were both statistically higher than that in mild PIH (P<0.05,P<0.01). Meantime the overlord of IECa2+ also showed positive relation to the degree of PIH and intrauterine asphyxia (P<0.05). Conclusions The CD62p,CD61,CD41 and IECa2+ levels can reflect the severity degree of PIH. The best method to decrease the harmfulness as result of overload IECa2+ is dropping hypertension by effective measures.
出处 《实用医药杂志》 2004年第2期103-105,共3页 Practical Journal of Medicine & Pharmacy
基金 全军"九五"科研基金项目(编号:98D016)
关键词 妊高征 血小板膜糖蛋白 红细胞内Ca^2+ 胎儿宫内窘迫 Pregnancy complications Platelet membrane glucoprotein Intracellular ionized calcium Intrauterine asphyxia
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