摘要
目的 对照研究磁共振质谱 (1H -MRS)与MRI对急性颈髓损伤的诊断价值。方法 根据 19例急性颈髓损伤患者的MRI表现 ,分为脊髓正常信号组 (损伤组Ⅰ )和脊髓异常信号组 (损伤组Ⅱ ) ,并以 9例健康者作对照。进行1H -MRS检查 ,并计算氮 -乙酰天门冬氨酸 (NAA)、胆碱 (Cho)、肌酸 (Cr)、乳酸 (Lac)波峰面积 ,分析NAA/Cho、NAA/Cr、Cr/Cho、Lac/Cho。结果 损伤组Ⅰ与对照组比 ,仅Lac/Cho值升高 (P <0 .0 5 )。损伤组Ⅱ与对照组比 ,NAA/Cho、NAA/Cr值降低 ,Lac/Cho值升高 (P <0 .0 1)。损伤组Ⅱ较损伤组ⅠNAA/Cho、NAA/Cr显著减低 (P <0 .0 5 )。结论 1H -MRS可定量测定创区颈髓相关代谢介质的变化 ,从代谢水平反映颈髓损伤的不同程度。MRI结合1H -MRS更有利于颈髓损伤评价。
Objective To evaluate the diagnosis of 1H-MRS and MRI for the acute spinal cord injury (ASCI). Methods 1H-MRS and MRI were performed on 19 patients of ASCI and 9 healthy volunteers with 1.5T 1H-MRS/MRI system. 19 patients were divided into two groups according to the MRI results as normal signal group (group I) and abnormal signal group (group II). The values of NAA,Cr,Cho and Lac were measured by integrating their peaks. The ratios of NAA/Cr?NAA/Cho?Cho/Cr?Lac/Cr were calculated and analyzed. Results The decrease of the ratios of NAA/Cr and NAA/Cho and the increase of the ratio of Lac/Cr were found in those patients with abnormal signal intensity of MRI (group II)( P <0.01). Only the ratio of Lac/Cho was decreased in those patients with normal signal of MRI (group Ⅰ)( P <0.05). The values of NAA/Cho?NAA/Cr in group II were lower than that in group I ( P <0.05). Conclusion 1H-MRS can be used in the quantitative analysis of metabolic abnormalities and can reflect the metabolic level of ASCI. The combination of MRI and 1H-MRS can provide even more useful information for the evaluation of ASCI.
出处
《脊柱外科杂志》
2004年第1期11-13,25,共4页
Journal of Spinal Surgery
关键词
急性颈髓损伤
^1H-MRS
MRI
磁共振质谱
诊断
acute spinal cord injury
magnetic resonance imaging
magnetic resonance spectroscopy
