摘要
目的:探讨多巴胺受体D2(dopaminereceptorD2,DRD2)TaqⅠ多态性与急性应激障碍(acutestressdisorder,ASD)遗传易患性的关系。方法:应用PCR-RFLP技术,对23例ASD患者的TaqⅠA多态性进行检测。对照组为41例经历过严重交通或其他意外事故的创伤幸存者。结果:对照组的A1等位基因频率(fA1)为24.4%,ASD组为43.5%,两者有显著性差异(χ2=4.998,P<0.05);对照组的A1等位基因携带率(pA1)为43.9%,ASD组为73.9%,两者差异显著(χ2=5.355,P<0.05)。结论:DRD2TaqⅠ多态性与急性应激障碍相关,A1等位基因的携带者可能对急性应激障碍易感。
AIM: To explore the relation between the polymorphism of dopamine receptor D2(DRD2) TaqⅠ and the genetic susceptibility of acute stress disorder (ASD). METHODS:PCR RFLP was used to determine the DRD2 TaqⅠ A polymorphism of 23 patients with ASD.Another 41 survivors,who had experienced serious traffic or other accidents,were involved in the control group. RESULTS:There were significant differences in A1 allele frequencies( fA1) between the ASD group(43.5% )and the control group(24.4% )(χ 2=4.998, P< 0.05).There were also significant differences in allele carrying rate between the ASD group(73.9% )and the control group(43.9% ) (χ 2=5.355, P< 0.05). CONCLUSION:Polymorphism of DRD2 TaqⅠ is related to the ASD,and A1 alleles carrier may be susceptibile to ASD.
出处
《中国临床康复》
CSCD
2004年第6期1086-1087,T002,共3页
Chinese Journal of Clinical Rehabilitation
基金
全军医药卫生科研基金资助项目(01L072)~~
