摘要
用[~3H]-thymidine参入法表明:益母草半日花烷型双环二萜——前益母草素(prehi-spanolone,LC-5504)对由Con A活化的T淋巴细胞有较强的促进增殖作用。其作用是单独使用Con A的5~8倍。实验研究提示,前益母草素能够增强机体的细胞免疫功能。
Leonurus hereterophyllus Sweet is a traditional Chinese herbal medicine used to treat
menstrual disturbances in woman. A new labclane diterpene, prehispanolone LC-5504, namely 9α,
13R, 15,16-diepoxy-labclane- 14-en- 7- one, had been isolated. The authors studied the synergism of
labdane diterpene,prehispanolone LC-5504 and Con A and LPS on T cells and B cells proliferation of
BALB/c female mouses in vitro. They showed that(1) proliferation of T cells was demonstrated by ad-
ministration of LC-5504 of various concentrations together with Con A. This proliferation was 5~8
times stronger than that observed when Con A was used alone. Such effect on T cells was not observed
when LC-5504 was used alone. (2) Proliferation of B cells was not observed whether LC-5504 was
used alone or together with LPS.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第11期812-816,共5页
Acta Pharmaceutica Sinica
关键词
益母草
B细胞
T细胞
双环二萜
Leonurus hereterophyllus Sweet
Labdane diterpene
Prehispenolone (LC--5504)
Lymphocyte proliferation
Lymphocyte T
Lymphocyte B