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前益母草素(prehispanolone)对小鼠T,B淋巴细胞的影响 被引量:19

PROLIFERATION OF LYMPHOCYTES T AND B BY PREHISPANOLONE LC-5504 OF LEONURUS HERETEROPHYLLUS SWEET
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摘要 用[~3H]-thymidine参入法表明:益母草半日花烷型双环二萜——前益母草素(prehi-spanolone,LC-5504)对由Con A活化的T淋巴细胞有较强的促进增殖作用。其作用是单独使用Con A的5~8倍。实验研究提示,前益母草素能够增强机体的细胞免疫功能。 Leonurus hereterophyllus Sweet is a traditional Chinese herbal medicine used to treat menstrual disturbances in woman. A new labclane diterpene, prehispanolone LC-5504, namely 9α, 13R, 15,16-diepoxy-labclane- 14-en- 7- one, had been isolated. The authors studied the synergism of labdane diterpene,prehispanolone LC-5504 and Con A and LPS on T cells and B cells proliferation of BALB/c female mouses in vitro. They showed that(1) proliferation of T cells was demonstrated by ad- ministration of LC-5504 of various concentrations together with Con A. This proliferation was 5~8 times stronger than that observed when Con A was used alone. Such effect on T cells was not observed when LC-5504 was used alone. (2) Proliferation of B cells was not observed whether LC-5504 was used alone or together with LPS.
出处 《药学学报》 CAS CSCD 北大核心 1992年第11期812-816,共5页 Acta Pharmaceutica Sinica
关键词 益母草 B细胞 T细胞 双环二萜 Leonurus hereterophyllus Sweet Labdane diterpene Prehispenolone (LC--5504) Lymphocyte proliferation Lymphocyte T Lymphocyte B
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  • 1劳红,细胞生物学杂志,1988年,10卷,82页 被引量:1
  • 2张陈福,中西医结合杂志,1986年,1卷,39页 被引量:1
  • 3柯铭清,中草药有效成分理化与药理特性(第2版),1982年 被引量:1
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