摘要
目的 :观察补肾活血中药加克罗米芬治疗多囊卵巢综合征 (polycysticovarysyndrome,PCOS)所致不孕的临床疗效。方法 :将排卵障碍所致不孕的 6 2例PCOS患者随机分为治疗组 (32例 )与对照组 (30例 ) ,治疗组采用补肾活血中药加克罗米芬治疗 ,对照组采用剂量与治疗组相同的克罗米芬治疗。结果 :治疗组治疗后内分泌激素水平较治疗前明显好转 ,雄激素、黄体生成素水平较治疗前明显下降。雌激素水平较治疗前明显升高 (P <0 0 1)。治疗组的周期排卵率达 87 0 % ,总妊娠率为 6 5 6 % ,未发生卵泡过度刺激综合征 (ovarianhyperstimulationsyndrome ,OHSS)及黄体化卵泡未破裂综合征 (luteinizedunrupturedfolliclesyn drome ,LUFS)。而对照组周期排卵率为 6 6 0 % ,总妊娠率 36 6 % ,有 4例并发LUFS。两组疗效比较差异有显著性 (P <0 0 5 )。结论 :补肾活血中药加克罗米芬治疗PCOS所致的不孕疗效明显高于单纯的克罗米芬治疗。
Objective:To observe the efficacy of combination therapy of clomiphene and Chinese drugs for nourishing Shen and activating blood circulation (NSABC) in treating Stein-Leventhal syndrome caused sterility. Methods:Sixty-two patients with anovulation caused sterility were randomly divided into the treated group (n=32) and the control group (n=30). The treated grop was treated with the combination therapy and the control group treated by the same dosage of clomiphene alone. Results:After treatment, when comparing with that before treatment, the endocrine hormones in the treated group improved significantly, showing a markedly decrease of androgen and luteotropic hormone, and increase of estrogen (P<0.001). The periodic ovulation rate in the treated group reached 87%, the total pregnancy rate being 65.6%, with no occurrence of ovarian hyperstimulation syndrome (OHSS) and luteinized unruptured follicle syndrome (LUFS), while in the control group, the periodic ovulation rate was 66%, the total pregnancy rate 36.6%, with LUFS occurred in 4 patients. Comparison of the therapeutic effects between the two groups showed significant difference (P<0.05). Conclusion:The combination therapy of clomiphene and NSABC has a better therapeutic effect in treating Stein-Leventhal syndrome caused sterility than that of using clomiphene alone.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2004年第1期41-43,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
补肾活血中药
克罗米芬
治疗
多囊卵巢综合征
不孕
临床观察
Stein-Leventhal syndrome, clomiphene, Chinese nourishing Shen and activating blood circulation drugs
