摘要
急性白血病要获完全缓解 (CR)必须经过化疗后的骨髓增生抑制期。在此期间外周血白细计数必然急剧减少。为了观察急性白血病化疗后白细胞 (WBC)计数与化疗疗效之间的关系 ,对 80例初治急性白血病患者在诱导化疗第 1疗程后WBC计数与疗效关系进行了分析。根据化疗后白细胞数的最低值分为 3组 :≤ 0 .4× 10 9/L组 ;(0 .4 - 0 .9)× 10 9/L组 ;>0 .9× 10 9/L组。结果表明 :初治急性白血病化疗第 1疗程后 ,WBC计数≤ 0 .4× 10 9/L的急性白血病CR率 6 0 % ,总有效率 90 % ;WBC计数在 (0 .4 - 0 .9)× 10 9/L的急性白血病CR率 5 5 .6 % ,总有效率 92 .6 % ;WBC计数 >0 .9× 10 9/L的急性白血病CR率 2 7.3% ,总有效率 6 6 .7%。白细胞≤ 0 .4× 10 9/L组 ,(0 .4 - 0 .9)× 10 9/L组与 >0 .9× 10 9/L组第 1疗程化疗有效率有显著性差异 (P <0 .0 1)。而白细胞≤ 0 .4× 10 9/L组与白细胞 (0 .4 - 0 .9)× 10 9/L组无明显差异。结论 :初发急性白血病第 1疗程化疗后白细胞计数可作为急性白血病化疗的一个预测指标。
To achieve the complete remission (CR), acute leukemia (AL) patient must get through the period of myloid ablation after chemotherapy that the white blood cell (WBC) count in peripheral blood decreases rapidly. To observe the relationship of WBC count with therapeutic effectiveness after chemotherapy in previously untreated AL, eighty cases of previously untreated acute leukemia who took the first induction chemotherapy course were analyzed. Blood routine was carried out 2 to 3 times every week while the bone marrow pictures on 12th and 20th day after chemothrapy were observed. 80 patients were divided into 3 groups based on the lowest value of WBC count after chemotherapy: ≤0.4×10 9/L group, (0.4-0.9)×10 9/L group and >0.9×10 9/L group. The results showed that the complete remission rates after the first course of chemotherapy were 60 vs 55.6 vs 27.3% respectively in the three groups which WBC counts were ≤0.4×10 9/L, (0.4-0.9)×10 9/L and >0.9×10 9/L. The total efficaciousness rates were 90 vs 92.6 vs 66.7 respectively in the three groups. The efficaciousness rate of the first two groups significantly differed from the third group ( P <0.01). However, no significant difference was shown between the first and second groups. It is concluded that the leukocyte count after the first course of chemotherapy may be an early indicator to predict the efficaciousness of chemotherapy.
出处
《中国实验血液学杂志》
CAS
CSCD
2004年第1期105-107,共3页
Journal of Experimental Hematology
关键词
急性白血病
诱导化疗
白细胞计数
acute leukemia
induction chemotherapy
white blood cell count
