摘要
目的 :探讨大鼠海马CA1区神经元缺血再灌注损伤的病理学改变及三七总皂苷 (PNS)的影响。方法 :线栓法制备大鼠左侧大脑中动脉阻断局灶性脑缺血模型。以临床神经症状缺损程度、海马CA1区组织学分级、海马CA1区神经元密度等为评价指标。结果 :三七总皂苷组神经症状明显减轻 ,海马CA1区组织学分级降低、神经元密度增加 ,与模型组间差异有显著性意义。结论 :三七总皂苷能明显减轻脑缺血再灌注引起的神经损伤症状及海马CA1区神经元损伤的程度。
Objective: To discuss on the pathology alteration of ischemical reperfusion injury in hippocampus CAI and the effect of panax notoginseng saporins on it. Methods: The focal cerebral ischemia model of middle cerebral artery blocked was prepared by locking with rope, with clinical neurotic reaction, histology classify of hippocampus CAI, neuron density in hippocampus CAI as evaluation marker. Results: The group with panax notoginseng saporins has distinctly efficacy, which neurotic reaction relieved distinctly, the grade of histology classify in hippocampus CAI has decreased and neuron density increased, with distinctly difference to model group. Conclusion: Panax notoginseng saporins could distinctly relieve the neurotic reaction and the injured degree of neuron in hippocampus CAI.
出处
《湖南中医药导报》
2004年第2期60-61,共2页
Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology
关键词
三七总皂苷
海马CA1区
缺血-再灌注损伤
Panax notoginseng saporins
Hippocampus CAI
Ischemia reperfusion injury
