摘要
以对硝基苯甲醚为原料,经还原、乙酰化、硝化、水解四步反应制得奥美拉唑中间体2-硝基-4-甲氧基苯胺,总 收率74.8％.反应条件温和,后处理简便,避免了使用硫酸二甲酯和发烟硝酸,减少了环境污染.
The p-nitroanisole was reducted, acetylized, nitrified and hydrolyzed to give the title compound N-(2-nitro-4-methoxy)phenylamine with the overall yield of 74.8%. The process has the advantages of mild reaction,low cost and less residue.
出处
《徐州师范大学学报（自然科学版）》
CAS
2003年第4期25-27,共3页
Journal of Xuzhou Normal University(Natural Science Edition)
