摘要
目的 :研究低氧复合游泳运动对大鼠血液流变学及心脏功能的影响。方法 :大鼠分为三组 :常氧对照组、低氧组和低氧复合游泳运动组。低氧大鼠每天在模拟海拔 4 0 0 0m低氧 1.5h后 ,升至 5 0 0 0m ,持续减压 2 3h/d ,共 5周。低氧运动大鼠每天在 4 0 0 0m模拟海拔游泳运动 1h(6d/w) ,然后升至 5 0 0 0m。多导生理记录仪测定心脏功能 ,E -型锥板粘滞度仪测定血液粘滞度 ,放射性生物微球法测定心输出量。结果 :低氧时 ,大鼠血球压积明显升高 ,全血粘度显著增加。低氧复合运动未引起血球压积的进一步升高 ,血液粘滞度显著降低。低氧组大鼠左、右室心肌最大舒缩速度显著提高 ,低氧复合运动后最大舒缩速度进一步提高 ,心输出量显著增加。结论 :在一定程度的低氧下 ,适当的体力活动可显著增强心脏功能 ,显著降低血液粘滞度。这种改变有利于改善低氧时机体各器官和组织的供氧状态 ,促进习服。
Aim: To study the effects of hypoxia alone or combined-exercise on blood viscosity and cardiac function of rats. Methods: 22 wistar rats were divided into 3 groups: Ⅰ normoxic control;Ⅱ hypoxia and Ⅲ hypoxia-combined exercise. Rats of Ⅱ and Ⅲ groups were subjected to hypobaric hypoxia for 5 weeks(23 h/day). They were first brought to simulated 4 000 m altitude, where rats of the Ⅲ group were forced to swim for 1 h/day(6 days/week). Then the animals were ascent to 5 000 m. Cardiac function were detected by polygraph, the blood viscosity was assayed by E-viswsimeter, 99m Tc radiolabelled frog red blood cell was used to measure the cardiac output. Results: Hypoxia alone caused an increase in blood hematocrit(Hct) and viscosity. Cardiac function of the left and right ventricles,especially ±dp/dt max was also increased. Hypoxia-combined-exercise did not cause further increase in Hct,while the blood viscosity was decreased. Cardiac function increased further in both ventricles and the cardiac output was increased by 20% after hypoxia-combined-exercise. Conclusion: During acclimatization to hypoxia,moderate exercise can decrease the blood viscosity and increase the cardiac function. These changes may be advantageous in delivering oxygen to tissues and may be favorable for promoting acclimation to high altitude.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2004年第1期7-10,共4页
Chinese Journal of Applied Physiology
基金
国家自然科学基金资助项目 (3 0 2 0 0 13 0 )
关键词
低氧
心脏
运动
血液流变学
hypoxia
heart
exercise
blood viscosity
