摘要
肿瘤需要能量代谢重组来维持能量供给与需求的平衡。肿瘤细胞重组的能量代谢包括有氧糖酵解、谷氨酰胺分解、逆向Warburg效应和截断的三羧酸循环。肿瘤细胞通过线粒体损伤、改变代谢关键酶、缺氧微环境和基因组改变实现有氧糖酵解。理解肿瘤能量代谢的方式和机制可以帮助研发逆转肿瘤能量代谢的新方法。
Cancers acquire reprogramming of energy metabolism to balance energy production and their biosynthetic needs. The altered metabolism includes aerobic glycolysis, glutaminolysis, reverse Warburg effect and truncated tricarboxylic acid cycle. Cancer cells principally rely on aerobic glycolysis through mitochondrial dysfunction, changes of key metabolic players, hypoxic microenvironment, and genomic changes. Understanding the style and mechanisms of cancer energy metabolism may lead to development of new approaches to reverse metabolic reprogramming.
出处
《肿瘤》
CAS
CSCD
北大核心
2014年第12期1157-1160,共4页
Tumor
基金
2013年甘肃省自然科学基金资助项目(编号:1308RJZA181)
