摘要
目的 :探究丁苯酞注射液联合氯吡格雷治疗进展性脑梗死(progressive cerebral infarction,PCI的疗效及对相关血清指标的影响。方法 :选取2017年2月—2018年4月我院收治的PCI患者76例,按随机数字表法分为观察组与对照组,各38例。对照组单纯予以硫酸氢氯吡格雷片(75 mg,qd)治疗,观察组予以丁苯酞注射液(25 mL,bid)联合氯吡格雷治疗,两组均连续治疗14 d。比较两组临床疗效,检测并观察两组治疗前后炎症反应指标、血管内皮功能指标、欧洲卒中评分(ESS)及日常生活能力(ADL)评分。结果 :观察组临床疗效高于对照组,差异有统计学意义(P <0.05);治疗后,观察组白细胞介素(IL)-1β、肿瘤坏死因子(TNF)-α、基质金属蛋白酶(MMP)-9低于对照组,差异有统计学意义(P <0.05);观察组一氧化氮(NO)、降钙素基因相关肽(CGRP)高于对照组,内皮素(ET)-1低于对照组,差异有统计学意义(P <0.05);观察组ESS、ADL评分均高于对照组,差异有统计学意义(P <0.01)。结论 :丁苯酞注射液联合氯吡格雷治疗PCI的疗效确切,可有效改善患者神经功能及血管内皮功能,抑制炎性反应,且预后良好,值得临床推荐。
Objective:To investigate the efficacy of butylphthalide injection combined with clopidogrel in the treatment of progressive cerebral infarction(PCI)and its effect on serum indexes.Methods:76 patients with PCI admitted to our hospital from February 2017 to April 2018 were selected and randomly divided into an observation group and a control group,38 cases each.The patients in the control group were treated with clopidogrel bisulfate tablets(75 mg,qd),and the patients in the observation group were treated with butylphthalide injection(25 m L,bid)combined with clopidogrel.The patients in the two groups were treated continuously for 14 days.The clinical efficacy were compared between the two groups.The inflammatory response indexes,vascular endothelial function indexes,European stroke score(ESS)and ability of daily living(ADL)scores before and after treatment were measured and observed.Results:The clinical efficacy in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin(IL)-1β,tumor necrosis factor(TNF)-αand matrix metalloproteinase(MMP)-9 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of nitric oxide(NO)and calcitonin gene-related peptide(CGRP)in the observation group were higher than those in the control group,while the level of endothelin(ET)-1 was lower than that in the control group,with statistically significant differences(P<0.05).The scores of ESS and ADL in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.01).Conclusion:Butylphthalide injection combined with clopidogrel is effective in the treatment of PCI,which can effectively improve neurological function and vascular endothelial functions and inhibit inflammatory response,and is good in prognosis and worthy of clinical recommendation.
作者
从林
冀书娟
Cong Lin;Ji Shu-juan(Ward I,Department of Neurology,Xinyang Central Hospital,Xinyang Henan 464000,China)
出处
《中国合理用药探索》
CAS
2019年第9期141-144,共4页
Chinese Journal of Rational Drug Use
关键词
丁苯酞注射液
氯吡格雷
进展性脑梗死
Butylphthalide Injection
Clopidogrel
Progressive Cerebral Infarction
