摘要
目的:分析应用左旋多巴和普拉克索对帕金森病患者精神状况和氧化应激的影响。方法 :选取我院2016年1月—2018年1月收治的帕金森病患者106例,按随机数字表法分为对照组和试验组,各53例。对照组应用左旋多巴(0.25～0.5 g,tid)治疗,试验组在对照组基础上联合普拉克索(0.125 mg,tid)治疗。比较两组的症状、抑郁程度、白细胞介素-1β、超氧化物歧化酶、丙二醛水平和安全性。结果 :治疗后试验组抑郁评分、帕金森评分量表(UPDRS)分值、白细胞介素-1β、丙二醛水平和不良反应发生率较对照组均明显降低,差异有统计学意义(P <0.05);治疗后试验组超氧化物歧化酶水平高于对照组,差异有统计学意义(P <0.05)。结论:应用左旋多巴和普拉克索能有效降低帕金森病患者的炎症和氧化应激程度,改善患者的精神状况和症状。
Objective:To analyze the effect of levodopa and pramipexole on mental status and oxidative stress in the patients with Parkinson’s disease.Methods:106 patients with Parkinson’s diseases admitted to our hospital from January 2016 to January 2018 were selected and randomly divided into a control group and an experimental group,53 cases each.The patients in the control group were treated with levodopa(0.25~0.5 g,tid),and the patients in the experimental group were treated with pramipexole(0.125 mg,tid)on the basis of the control group.The symptoms,depression degree,interleukin-1β,superoxide dismutase and malondialdehyde levels and safety were compared between the two groups.Results:After treatment,the depression scores,UPDRS scores,interleukin-1β,malondialdehyde levels and adverse reaction rate in the experimental group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the level of superoxide dismutase in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Levodopa and pramipexole can effectively reduce the degree of inflammations and oxidative stress in the patients with Parkinson’s diseases and improve their mental status and symptoms.
作者
张璐
Zhang Lu(Department of Neurology,Tanghe County People’s Hospital,Nanyang,Henan,473400,China)
出处
《中国合理用药探索》
CAS
2019年第4期142-144,共3页
Chinese Journal of Rational Drug Use
关键词
普拉克索
氧化应激
帕金森病
炎症
症状
Pramipexole
Oxidative Stress
Parkinson’s Disease
Inflammation
Symptom
