摘要
目的:综合分析异丙酚在小儿全凭静脉复合麻醉中的应用价值。方法:选取2014年12月—2016年12月我院收治的54例需手术治疗而接受全凭静脉复合麻醉的患儿,按随机数字表法分为试验组和对照组,各27例。试验组应用异丙酚与氯胺酮麻醉,手术前15 min静脉泵注异丙酚1 mg/kg,和氯胺酮2 mg/kg,10 min后泵注异丙酚与氯胺酮复合液(5%葡萄糖注射液100 m L+100 mg氯胺酮+200 mg异丙酚);对照组应用右美托咪定与氯胺酮麻醉,手术前15 min缓慢静注右美托咪定1μg/kg,根据手术刺激强度追加0.5~1 mg/kg氯胺酮,在30 s内匀速静脉注入,随后持续静脉泵入氯胺酮1 mg/(kg·h)。比较两组不同时间段(用药前、给药后5 min、切片、缝合、清醒时)的收缩压(SBP)、血氧饱和度(Sp O2)、心率(HR)、平均麻醉时间、平均清醒时间、定向力恢复时间、麻醉优良率以及不良反应发生情况等。结果 :(1)用药前,两组SBP、Sp O2、HR比较,差异无统计学意义(P>0.05);给药后5 min、切片、清醒时试验组SBP、HR低于对照组(P<0.05),切片时Sp O2高于对照组(P<0.05);(2)试验组平均麻醉时间、平均清醒时间、定向力恢复时间短于对照组(P<0.05);(3)试验组麻醉优良率显著高于对照组(P<0.05),不良反应发生率显著低于对照组(P<0.05)。结论 :异丙酚在小儿全凭静脉复合麻醉中的应用价值高。
Objective: To comprehensively analyze the application value of propofol in total intravenous anesthesia in children. Methods: 54 children who underwent operation and received total intravenous anesthesia in our hospital from December 2014 to December 2016 were randomly divided into experimental group and control group, 27 cases in each group. The children in the experimental group were given propofol and ketamine anesthesia; propofol 1 mg/kg and ketamine 2 mg/kg were administered by intravenous infusion 15 min before operation, and 10 min later, compound solution of propofol and ketamine(5% glucose injection 100 m L + 100 mg ketamine + 200 mg propofol) was administered by infusion. The children in the control group were given dexmedetomidine and ketamine anesthesia; dexmedetomidine 1 μg/kg was administered by slow intravenously injection 15 min before operation, and according to the stimulation intensity of the operation, 0.5~1 mg/kg ketamine was administered by uniform intravenous injection within 30 s, and then ketamine 1 mg/(kg·h) was administered by continuous intravenous infusion. Systolic blood pressure(SBP), blood oxygen saturation(Sp O2), heart rate(HR), average anesthesia time, average awake time, recovery time of orientation force, excellent and good anesthesia rate and adverse reactions at different time stages(before administration, 5 min after administration, section time, suture time, awaking time) were compared between the two groups. Results: Before treatment, there was no significant difference in SBP, Sp O2 and HR between the two groups(P>0.05); SBP and HR at 5 min after administration, section time and awaking time in the experimental group were lower than those in the control group, and Sp O2 at section time was higher than that in the control group(P<0.05); the average anesthesia time, average awake time and recovery time of orientation force in the experimental group were shorter than those in the control group(P<0.05); the excellent and good anesthesia rate in the experimental group was s
出处
《中国执业药师》
CAS
2018年第10期14-16,共3页
China Licensed Pharmacist
关键词
异丙酚
小儿全凭静脉复合麻醉
应用价值
Propofol
Total Intravenous Anesthesia Child
Application Value
