摘要
目的:观察小剂量胺碘酮联合倍他乐克治疗肥厚型心肌病伴恶性室性心律失常对心电图指标及预后的影响。方法:选择2016年3月-2017年2月我院收治的肥厚型心肌病伴恶性室性心律失常患者60例,按随机数字表法分为对照组与试验组,各30例。对照组应用倍他乐克(初始剂量:6.25 mg,bid;维持剂量:12.5 mg,bid)治疗,试验组在对照组基础上加用小剂量胺碘酮(初始剂量:200 mg,tid;维持剂量:100 mg,tid)联合治疗。观察治疗后两组心电图指标及预后情况。结果:治疗后,试验组QT离散度低于对照组,最短QT间期高于对照组,差异有统计学意义(P<0.05);两组最长QT间期比较差异无统计学意义(P>0.05);试验组临床总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,试验组再住院率显著低于对照组,差异有统计学意义(P<0.05),两组猝死率及不良反应比较均无统计学差异(P>0.05)。结论:应用倍他乐克与小剂量胺碘酮联合治疗肥厚型心肌病伴恶性室性心律失常效果显著,可有效改善心电图指标及预后,且安全性高。
Objective:To observe the effect of low-dose amiodarone combined with betaloc on electrocardiogram(ECG) indexes and prognosis in patients with hypertrophic cardiomyopathy complicated with malignant ventricular arrhythmia. Methods:60 cases of patients with hypertrophic cardiomyopathy complicated with malignant ventricular arrhythmia admitted to our hospital from March 2016 to February 2017 were selected and divided into control group and trial group according to the random number table method, 30 cases in each group. The patients in the control group were treated with betaloc(initial dose: 6.25 mg, bid; maintenance dose: 12.5 mg, bid), and the patients in the trial group were further treated with low-dose amiodarone(initial dose: 200 mg, tid; maintenance dose: 100 mg, tid) based on the control group. The ECG indexes and prognosis in the two groups after treatment were observed. Results:After treatment, the QT dispersion in the trial group was significantly lower than that in the control group, and the shortest QT interval in the trial group was significantly higher than that in the control group(P<0.05); there was no significant difference in the longest QT interval between the two groups(P>0.05); the total effective rate in the trial group was significantly higher than that in the control group(P<0.05); the rate of rehospitalization in the trial group was significantly lower than that in the control group(P<0.05), and there was no significant difference in sudden death rates and adrerse reactions between the two groups(P>0.05). Conclusion:The combination of betaloc combined with low-dose amiodarone has significant efficacy in the treatment of hypertrophic cardiomyopathy complicated with malignant ventricular arrhythmia, which can effectively improve ECG indexes and prognosis, and has high safety.
出处
《中国执业药师》
CAS
2018年第6期29-32,共4页
China Licensed Pharmacist
关键词
肥厚型心肌病
小剂量胺碘酮
倍他乐克
心电图指标
预后效果
Hypertrophic Cardiomyopathy
Low Dose Amiodarone
Betaloc
Electrocardiogram Indexes
Prognosis Effect
