摘要
目的探讨辅助生殖技术治疗不孕不育患者妊娠失败的相关影响因素。方法选取2016年8月~2018年8月于我院行ART不孕不育患者904例为研究对象。根据妊娠情况分为妊娠失败组217例和妊娠持续组687例。收集两组患者相关资料,采用单因素和多因素分析法分析比较妊娠失败相关影响因素。结果本研究ART治疗方法IVF-ET妊娠失败率为24.44%,ICSI妊娠失败率为22.71%,两者比较差异无统计学意义(χ2=0.283,P=0.595);失败组年龄显著高于持续组,差异具有统计学意义(t=13.064,P<0.001);BMI、hCG日内膜厚度、优质胚胎数均显著低于持续组,差异具有统计学意义(t=5.896、4.935、9.480,P<0.001),且经Logistic回归分析显示,年龄、hCG日内膜厚度与ART妊娠失败显著相关(显著性=0.000、0.045),BMI与优质胚胎数相关性不大(显著性=0.387、0.576)。结论不孕不育患者行辅助生殖技术妊娠失败的相关影响因素较多,主要影响因素为年龄、hCG日内膜厚度。患者应尽早行辅助生殖技术治疗。
Objective:To investigate the related factors of pregnancy failure in infertile patients treated with assisted reproductive technique.Methods:904 cases of ART infertility in our hospital from August 2016 to August 2018 were selected as the study subjects.According to the situation of pregnancy,217 cases were divided into failure group and 687 Cases were divided into persistent pregnancy group.Relevant data of two groups of patients were collected,and the influencing factors of pregnancy failure were analyzed and compared by univariate and multivariate analysis.Results:The failure rate of IVF-ET pregnancy and ICSI pregnancy was 24.44%and 22.71%respectively.There was no significant difference between them(χ2=0.283,P=0.595);the age of failure group was significantly higher than that of persistent group,the difference has statistical significance(t=13.064,P<0.001);the intimal thickness and the number of high-quality embryos of BMI and hCG were significantly lower than that of persistent group,the difference has statistical significance(t=5.896、4.935、9.480,P<0.001),and logistic regression analysis showed that age,hCG day intimal thickness and ART pregnancy failure were significantly correlated(significant=0.000,0.045),BMI was not significantly correlated with the number of high-quality embryos(significant=0.387,0.576).Conclusion:There are many factors related to the failure of assisted reproductive technology(ART)pregnancy in infertility patients.The main factors are age and intimal thickness of hCG day.Patients should be treated with assisted reproductive technology as soon as possible.
作者
封旭
李文
孙宁霞
FENG Xu;LI Wen;SUN Ning-xia(Shanghai Changzheng Hospital 200003)
出处
《中国优生与遗传杂志》
2019年第9期1131-1132,1135,共3页
Chinese Journal of Birth Health & Heredity
关键词
不孕不育
辅助生殖技术
妊娠结局
妊娠失败
影响因素
Infertility
Assisted reproductive technology
Pregnancy outcome
Pregnancy failure
Influencing factors
