摘要
Objective To investigate the correlations betweenthe expression of the slingshot-1(SSH1) and the generalclinicopathological factors in gastrointestinal stromaltumor (GIST) patients. Methods Immunohistochemicalstaining was used to detect the expression of SSH1 proteinin 96 gastrointestinal stromal tumors,and the correlationsbetween expression level of SSH1 and generalclinicopathological factors were analyzed. Results Totally,there were 96 cases of GIST patients (49 males and47 males),with a mean age of (55. 80 ± 12. 33) years.The tumors were located in different organs: 62 cases(64. 6%) in the stomach,29 cases (30. 2%) in the intestine,and 5 cases (5. 2%) in other organs,with amean tumor size of (5. 11 ± 3. 73) cm. The low riskgroup contained 57 cases ( 59. 4%), 18 cases(18. 8%) in middle risk group and 21 cases (21. 9%)in high risk group. The pathological examination showedthat the positive expression rate of CD117,CD34,DOG-1, Ki-67, SMA, S-100 and Desmin was 85. 4%,84. 4%,86. 5%,90. 6%,10. 4%,3. 1% and 2. 1%,respectively. In 96 cases of GIST,37 cases (38. 5%)had high expression of SSH1,and SSH1 expression levelwas correlated with the tumor invasion depth,risk classification,tumor mitotic figure count,CD34 ( + ) (P <0. 05).
