摘要
Objective To observe functional changes of renal tubular epithelial cells stimulated by high mobility group protein box 1(HMGB1)and associated mechanism.Methods Renal tubular epithelial cells(NRK52E)were divided into control group,HMGB1 group and HMGB1+lipopolysaccharide from Rhodobactersphaeroides(LPS RS)group.Toll-like receptor 4(TLR4)expression