摘要
目的系统评价参附注射液治疗心力衰竭患者的临床疗效。方法检索近3年CHKD期刊全文数据库、CHKD博硕士学位论文全文数据库、万方数据库公开发表的西药常规加参附注射液与单纯西药常规比较治疗心力衰竭的临床随机对照试验,将符合纳入标准的试验纳入本次研究,采用Review Mananer5.0软件对其进行Meta分析。结果共纳入25个研究,合计1975例患者。Meta分析结果显示,西药常规加参附注射液治疗组和单纯西药常规治疗组在治疗心力衰竭有效率差异有统计学意义[OR=3.55,95%CI(2.69,4.69),P<0.00001];对改善治疗后心脏超声指标LVEF[WMD=5.78,95%CI(3.86,7.70)]、LVDD[WMD=-1.52,95%CI(-2.43,-0.61)]均有显著差异(P<0.01);对降低心衰患者BNP[WMD=-98.30,95%CI(-143.81,-52.78)]水平有显著差异(P<0.00001)。结论本研究采用Meta分析进行统计学处理,结果显示西药常规加参附注射液治疗心力衰竭的疗效优于单纯西药常规治疗。
Objective: To assess the curative effect of Shenfu injection on patients with heart failure. Method:Data was retrieved in clinical randomized controlled trials literature in the periodical full-text database of CHKD,doctor- master degree theses full-text database of CHKD and the database of Wangfang,which included the treatment of patients with heart failure with western medicine plus Shenfu Injection versus simple western medicine. Data analysis was conducted by the Review Mananer5.0. Results: A total of 25 studies(1975 patients)were inclueded. The results of this meta-analysis showed that the curative effect of western medicine plus Shenfu Injection group and the simple western medicine group had significant difference in the patients with heart failure[OR=3.55,95%CI(2.69,4.69),P < 0.00001],and in improving the after-treated echocardiographic indexes(P <0.01): LVEF [WMD =5.78,95% CI(3.86,7.70)],LVDD [WMD =-1.52,95% CI(-2.43,-0.61)] and reducing the level of BNP [WMD=-98.30,95% CI(-143.81,-52.78)] in patients with heart failure(P < 0.00001). Conclusion: The result of this meta-analysis shows that the curative effect of the treatment on patients with heart failure with western medicine plus Shenfu Injection is better than simple western medicine.
出处
《中国中医急症》
2015年第10期1717-1719,1730,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
广东省中医药局科研课题(20132031)
