摘要
目的:探讨肝失疏泄在正常人体衰老进程中的影响作用,为阐释肝在衰老进程中的重要地位提供科学依据。方法:采用病例对照研究,根据艾森克人格问卷(EPQ)得分,确定高神经质和低神经质受试者各30例,应用酶联免疫吸附实验方法(ELISA)测定研究对象尿中8-羟基脱氧鸟苷(8-OHdG)与血浆中脂质过氧化产物(LPO)、超氧化物歧化酶(SOD)含量。结果:与低神经质组相比,高神经质组尿8-OHdG与血浆中LPO和SOD水平均显著升高(P<0.05);EPQ中神经质项目得分与8-OHdG(r_s=0.318)和LPO(r_s=0.331)之间存在明显的正相关(P<0.05),与SOD间相关性无统计学意义(P>0.05)。结论:肝失疏泄能够加速人衰老进程,其机制可能与肝失疏泄引发情绪应激进而产生氧化应激有关。
Objective:To investigate the effects ofliver failing to dispersein the aging process of normal humansand provide a scientific basis for explaining the important role of liver in the aging process.Methods:A case-control study was conducted.According to the EPQ score,30 patients with high neuroticism and low neuroticism were identifiedrespectively.Urine8-hydroxy-2 deoxyguanosine(8-OHdG),lipid peroxidation product(LPO)and superoxide dismutase(SOD)in plasma were determined by enzyme-linked immunosorbent assay(ELISA).Results:Compared with the low neurotic group,8-OHdG,LPO and SOD in the high neurotic group were significantly higher(P<0.05).A significant positive correlation was found between neurotic item scores in EPQ and 8-OHdG(r_s=0.318)as well as LPO(r_s=0.331).Conclusion:If liver fails to disperse,it can accelerate the aging process,and the mechanism may be related tooxidative stress caused bythe emotional stress.
作者
刘紫阳
詹向红
赵紫薇
刘秀灵
LIU Ziyang;ZHAN Xianghong;ZHAO Ziwei;LIU Xiuling(Shandong Uinversity of Traditional Chinese Medicine,Jinan 250355,Shandong,China;Henan Uinversity of Traditional Chinese Medicine,Zhengzhou 450046,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2019年第6期1352-1355,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81173148,81473556)
关键词
肝失疏泄
神经质
衰老
liver failing to disperse
neuroticism
aging
