摘要
目的:探讨小檗碱对精神分裂症患者认知功能的影响。方法:符合精神障碍统计与诊断手册第五版(DSM-5)诊断标准的门诊和住院精神分裂症患者69例,随机分为小檗碱组(利培酮合并小檗碱,n=34)和对照组(利培酮合并安慰剂,n=33),采用精神分裂症认知功能成套测验中文版(M CCB)对两组患者治疗前(0周)及治疗12周末进行测试,评估患者的认知功能主要是学习记忆和信息处理速度功能。其中霍普金斯词语学习测验(HVLT-R)、简单视觉空间记忆测验(BVMT-R)和空间广度测验(WMS-III)来测查学习记忆功能,连线测验(TMT)、符号编码(SC)、Stroop色词试验测查患者对信息的处理速度。结果:组内比较发现两组治疗12周末的各项测验得分变化均具有统计学意义(P<0.05),进一步对差值进行秩和检验发现,小檗碱组的分数变化大于对照组(P<0.05)。在第12周末,小檗碱组患者与对照组相比,HVLT-R3试[(8.9±0.8)vs.(8.2±0.9)]、BVMT-R[1试,(-6.9±0.9)vs.(5.6±0.9);2试,(7.6±0.8)vs.(7.0±0.9);3试(10.6±1.4)vs.(8.1±0.6)]、WMS-III的顺行测验(8.6±0.8)vs.(8.1±0.8)、TMT[(35.6±3.7)vs.(44.2±4.7)]、SC[(46.2±2.3)vs.(37.5±4.2)]成绩均高于对照组(均P<0.05)。结论:小檗碱可有效改善精神分裂症患者的认知功能,尤其是学习记忆以及信息处理速度。
Objective:To study the effect of berberine on the cognitive ability in schizophrenia patients.Methods:The schizophrenia patients met with the Diagnostic and Statistical Manual of Mental Disorders(DSM-5) criteria were randomly divided into berberine group(risperidone combined with berberine) and control group(risperidone combined with placebo).Marrics Consensus Cognitive Battery(MCCB) was used to test the two groups of patients before treatment(0 weeks) and the end of 12 th weeks.Using the Hopkins Verbal Learning Test-Revised(HVLT-R),Brief Visuospatial Memory Test-revised(BVMT-R) and Wechsler Memory Scale-Ⅲ(WMS-Ⅲ) to examine the function of learning and memory,and the Line test(TMT),Symbol encoding(SC),Stroop Color Word Test to examine the speed of information processing.Results:There were significant differences in score changes between the two groups(P <0.05).The improvement effect of the experimental group were significantly different compared with the control group analyzed by the nonparametric test(P < 0.05).At the end of the12 th week berberine group patients with simple visual spatial memory test BVMT-R(I:(-1.21 ±0.79) vs.(-0.06 ±0.42),Ⅱ:(-1.00 ±0.54) vs.(-0.53 ±0.71),Ⅲ:(-2.86 ± 1.01) vs.(-0.24 ±0.43),Hopkins words learning test(HVLT-R) Ⅲ(-1.14 ±0.59) vs.(-0.24 ±1.13),Wechsler spatial span test WMS-Ⅲ(-0.96 ±0.35) vs.(-0.33 ±0.25) TMT(10.29 ±2.29) vs.(1.71 ±1.19) and SC(10.71 ± 1.98 vs.(1.88 ±0.91) scores were significantly superior to those in the placebo groups.Conclusion:It suggests that berberine could effectively improve the learning memory function and the speed of information processing inpatients with schizophrenia.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2016年第9期677-682,共6页
Chinese Mental Health Journal
关键词
精神分裂症
小檗碱
学习记忆
信息处理速度
schizophrenia
berberine
learning and memory
information processing
