摘要
一种新药与传统应用的有效药物进行对比,是评价新药疗效的重要方面。治疗钩端螺旋体病(简称钩体病)新的化学合成药物咪唑甲酸乙酸乙酯(ethy14(5)-imidazolecarboxylate 简称咪唑酸酯,代号'751')自研制以来。
Studtes were carried out to compare the therapeutic effects of "751" (ethyl 4(5)—imidazolecarboxylate) and penicillin against leptospira infection in golden hamsters.The treatment was started 24 hr or 48 hr after challenge with 100 or 1000 LO_(50) of highly virulent Leptospira icterohae morrhagiae and the animals were observed for 14 days thereafter.The dosages of the drugs were the lowest dose usually used in clinical treatment of leptosp— irosis and 2 times or 3 times of that dose.In another experiment,animals were challenged with 100 LO_(50) of leptosipra 48 hr after intraperitoneal injection of cyclophosphamide and treated with 3 times the lowest clinical dose.The results indicated that the survival rates in Penicillin and"751" treated groups were 90～100% and 3.3～60% respectively when the animals were challenged with 100 LO_(50).when the infection dose was increased to 1000 LD_(50) or the animals were immunosuppressed,the therapeutic effects of"751" decreased markedlly,while those of penicillin were not influenced It is considered that"751" has certain therapeutic efficacy against leptospira infection in golden hamsters,but in comparison to penicillin its efficacy emains to be investigated.
