摘要
目的 探讨非小细胞肺癌 (Non smallcelllungcancer ,NSCLC)组织中细胞周期蛋白D1(cyclinD1)的表达及其与预后的关系。方法 对 73例原发性NSCLC组织和 2 0例良性肺部疾病组织进行免疫组织化学染色检测其cyclinD1,并结合临床资料进行分析。结果 良性肺部疾病组织 2 0例中cyclinD1的阳性率为 15 %。 73例NSCLC组织中cyclinD1阳性表达率为 64 4% ,且在肺鳞癌、腺癌组织中表达的差异无显著性。有淋巴结转移组其CyclinD1阳性率明显高于无淋巴结转移组 ,P <0 0 5 ,Ⅰ～Ⅱ期cyclinD1表达的阳性率高于Ⅲ～Ⅳ期 ,P <0 0 5。结论 CyclinD1的过表达与NSCLC的发生、发展有密切相关 。
Objective To investigate the expression of cyclinD1 in Non small cell lung cancer (NSCLC)and its relationship to prognosis Methods The cyclinD1 was detected by immunhistochemical staining(SP)in 73 cases of primary NSCLC and 20 cases of benign disease,and the clinical data were analyzed Results The incidece of cyclinD1 expression was 15%in benign disease,but it was 64 4% in the 73 cases of NSCLC There was no statistical significance of the positive expression rate of cyclinD1 in squamous carcinomas and adenocarcinomas.There was higher expression of cyclinD1 in the group of lymph node metastasis( P <0 05)and the positive expression rate of cyclinD1 of NSCLC in Ⅰ～Ⅱstage were higher than that in Ⅲ～Ⅳ stage( P <0 05) Conclusion There is close corrlation between the expression of cyclinD1 and the formation of NSCLC,and the level of cyclinD1 is valuable in guiding the diagnosis and the estimation of these patients' prognosis
出处
《四川医学》
CAS
2004年第2期154-155,共2页
Sichuan Medical Journal
