摘要
目的 探讨血清可溶性E 选择素 (sE selectin)浓度与血压水平、肥胖度、血糖及血脂等的关系。方法 测定 95例无靶器官损害的 1级原发性高血压患者 (HT组 )和 35例正常血压者 (NT组 )的空腹血清sE selectin浓度、收缩压 (SBP)、舒张压 (DBP)、体重指数 (BMI)、空腹血糖 (FPG)、总胆固醇 (TC)和三酰甘油 (TG)。分析血清sE selectin浓度与其他各项参数的相关性。结果 ①HT组血清sE selectin浓度为 ( 4 2 .5± 15 .3) μg/L ,高于NT组的 ( 33.2± 14 .8) μg/L(P <0 .0 1) ,但经协方差较正BMI后 ,两组间血清sE selectin浓度的差异无显著性 ;②两组 ( 130例 )的血清sE selectin浓度为 ( 4 0 .0± 15 .7) μg/L ,与SBP、DBP、BMI和TG呈显著正相关(P值分别 <0 .0 5和 <0 .0 0 1) ;③在剔除超重、体重过轻者后 ,HT组 ( 2 9例 )与NT组 ( 30例 )的血清sE selectin浓度分别为 ( 37.5± 12 .3) μg/L和 ( 35 .2± 15 .0 ) μg/L ,两组差异无显著性 ,但仍与BMI显著相关 ,而与血压值不相关。结论 无靶器官损害的 1级原发性高血压患者和正常血压者血清sE selectin浓度与血压不相关 。
Objective To explore the relevance of serum soluble E selectin (sE selectin) level and blood pressure, degree of obesity, blood glucose and serum lipid in hypertensives. Methods Serum sE selectin concentrations were measured by enzyme immunoassay. Systolic pressure (SBP), diastolic pressure (DBP), body mass index (BMI), fasting blood glucose, total cholesterol, triglyceride (TG) were determined in 95 uncomplicated patients with grade 1 hypertensives and 35 normotensives. The correlation between sE selectin and other parameters were analyzed.Results ① The level of sE selectin was significantly higher in hypertensives group [(42.5±15.3) μg/L] than that in normotensives group [(33.2±14.8) μg/L, P <0.01]. The difference of serum sE selectin concentrations between the two groups disappeared when BMI was corrected by analysis of covariance. ② Serum sE selectin concentrations [(40.0±15.7) μg/L] in both groups were positive significantly correlated with SBP 、DBP、BMI、TG( P <0.05 and <0.001). ③ If patients with overweight and underweight were excluded, the difference of serum sE selectin concentrations between the two groups were not significant,but were correlated with BMI ( P <0.05), and no longer related to blood pressure. Conclusion Serum sE selectin concentrations are not directly related to the blood pressure in uncomplicated grade 1 hypertensives and normotensives, but are actually in close relation with the degree of obesity.
出处
《上海医学》
CAS
CSCD
北大核心
2004年第1期7-9,共3页
Shanghai Medical Journal
