摘要
以伪狂犬病毒为模式病毒,按照仔猪体质量分别将100、10、1μg/kgCpG序列同猪伪狂犬疫苗联合免疫接种仔猪,检测仔猪的体液及细胞免疫反应.试验结果表明:不同浓度的CpG序列均能显著提高仔猪的特异性抗体滴度、白细胞介素(IL) 2诱生活性以及淋巴细胞增殖反应,证明CpG序列能显著增强仔猪对常规疫苗的免疫应答能力.
Piglets were inoculated with CpG motifs and pseudorabies attenuated vaccine simultaneously, the CpG motifs inoculation dosages were 100, 10, 1 μg/kg, respectively. The titer of specific antibodies to pseudorabies attenuated vaccine, the proliferation of lymphocytes and induced IL-2 activities were assessed. The results showed that the above-mentioned immune response of the piglets to vaccine with different dosages of CpG motifs added was significantly stronger than conventional immunization.
出处
《华南农业大学学报》
CAS
CSCD
北大核心
2004年第1期96-98,共3页
Journal of South China Agricultural University
基金
广东省农业攻关项目(2003B21403)
广州市重点攻关项目(2003ZR E0221)
关键词
剂量
CPG序列
仔猪
免疫增强效果
CpG motifs
immune response
piglets
pseudorabies attenuated vaccine
