摘要
5-羟色胺转运体在情感性精神障碍的发病中起着重要作用,其与抑郁障碍的关联研究一直是热点话题。5-羟色胺转运体基因被认为是抑郁障碍的首要候选基因。目前有关抑郁障碍的药物基因组学研究多集中在5-羟色胺神经递质相关基因上,但其与抑郁障碍的病因及治疗的关联研究未有一致结论。笔者结合国内外研究进展,围绕5-羟色胺转运体的生物学特性、5-羟色胺转运体基因多态性与抑郁障碍的关系及5-羟色胺转运体基因多态性与选择性五羟色胺再摄取抑制剂抗抑郁疗效三方面作一综述。
Serotonin transporter plays an important role in the onset of affective disorder,and its association with depression has been a hot topic.Serotonin transporter gene is considered as the first candidate gene for depressive disorder.At present,the research on pharmacogenomics of depression is mostly focused on serotonin neurotransmitter related genes,but there is no consistent conclusion between the etiology and treatment of depressive disorders.According to the research progress at home and abroad,the author did a summary from three aspects:the biological characteristics of serotonin transporter,the relationship between serotonin transporter gene polymorphism and depressive disorders and the relationship between the serotonin transporter gene polymorphism and selective serotonin reuptake inhibitor antidepressant efficacy.
出处
《中华临床医师杂志（电子版）》
CAS
2017年第8期1366-1369,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
国家自然科学基金面上项目(81471379)
山西省自然科学基金面上项目(2014011041-1)
山西省应用基础研究项目青年科技研究基金(201601D021150)
山西医科大学博士启动基金(03201314)
