摘要
自噬(autophagy)是细胞依赖溶酶体降解受损的细胞器及大分子物质过程。非脂肪细胞出现脂质沉积时,机体通过脂肪代谢产物、氧化应激、内质网应激等途径激活自噬,降解脂滴以保护非脂肪组织免受脂毒性损害。因此增强自噬可能是治疗2型糖尿病、非酒精性脂肪性肝病、代谢综合征等脂肪异位沉积相关疾病的新途径。本文就自噬与脂肪异位沉积的研究进展进行综述。
Autophagy is the degradation of damaged organelles and macromolecules which dependents on lysosomal. When non-fat cells embody lipid, autophagy is activated by fat metabolism, oxidative stress, endoplasmic reticulum stress, recent studies show that autophagy can degrade intracellular lipid droplets(LDs) to protect non-adipose tissue from lipid toxicity. Enhanced autophagy may be the new approach to treat diseases related to ectopic fat deposition, such as type 2 diabetes mellitus, non-alcoholic fatty liver disease, metabolic syndrome. In this paper, the researches on autophagy and ectopic deposition of lipids were reviewed.
出处
《中华临床医师杂志（电子版）》
CAS
2016年第18期2776-2779,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
山西省归国留学基金资助项目(2011-108)
山西省自然科学基金课题(2013011048-3)
山西省卫计委科技攻关计划项目(2014002)
关键词
自噬
脂肪异位沉积
脂滴
Autophagy
Ectopic deposition of lipids
Lipid droplet
